When it comes to anticoagulants, many people don't understand what they are used for. Simply put, anticoagulants are chemicals that prevent blood clotting. It is very commonly used in blood collection tubes used in hospitals to collect blood for testing. In different blood tests, the applicable anticoagulants are also different. Commonly used anticoagulants include EDTA, sodium citrate, heparin, etc. Let's take a look at the mechanism of action of these anticoagulants.
Because blood coagulation is divided into three main stages: first, prothrombin activator is formed; second, prothrombin activator catalyzes the conversion of prothrombin into thrombin; third, thrombin catalyzes the conversion of fibrinogen into fibrin . In these three stages, the participation of calcium ions is required, so once the chelated calcium ions are removed, the blood loses the necessary conditions for coagulation and cannot be coagulated.
1. EDTA (ethylenediaminetetraacetic acid)
There are three different forms of EDTA ethylenediaminetetraacetic acid anticoagulant, namely EDTA dipotassium, EDTA tripotassium, and EDTA disodium. Tripotassium EDTA is relatively easier to dissolve and is more popular than other forms. EDTA plays an anticoagulant effect mainly by chelating calcium ions and removing free calcium ions.
2. Sodium citrate
Sodium citrate combines with free calcium to form a sodium citrate complex, which consumes calcium to achieve anticoagulant effect. The recommended anticoagulant concentration is 3.2% or 3.8%. The ratio of anticoagulant to blood is 1:9 and 1:4. Blood after sodium citrate anticoagulation cannot be used for compressed cell volume (PCV), hemoglobin (Hb) estimation, total white blood cell count TLC, and differential white blood cell count (DLC) because citrate is used as a solution and it changes blood concentration.
3. Heparin
Heparin is an acid mucopolysaccharide with affinity for blood proteins and can be used as antithrombin and antithromboplastin. It prevents the conversion of prothrombin into thrombin, thereby playing an anticoagulant effect. As an anticoagulant, heparin is often used in emergency biochemistry and blood rheology testing.
Supplier: Tempered glass, laminated glass, mirror, acid etched glass, fritted glass, float glass, reflective glass, low e glass, patterned glass, glass bottle, glass jar, glassware, glass tube, glass cup
Acid etched glass is annealed glass treated with acid to give its surface a frosted look. Entire sheets of glass can be acid etched, or small sections can be treated to add specific designs. It make glass artistic, beautiful and long lasting. Normal acid etched glass can be used to create doors, partitions, walls, shelves, and railings, special items can be used as â??anti-glare glassâ?? for picture frame, screen, etc. Product items :� single side acid etched glass / double side acid etched glass Thickness :2-19mm Size :2440x3660mm 2140x3300mm,1830x2440mm,1220x1830mm, any cut sizes