Citrate is mainly used for hemostasis testing and the determination of erythrocyte sedimentation rate. Generally, the INP value of sodium citrate with a concentration of 0.129mol/L is higher than that with a concentration of 0.109mol/L. In addition, for thromboplastin reagents from different sources, the clotting time of the plasma of the same normal person or patient can vary greatly . Therefore, the source of the thromboplastin reagent used in each laboratory should be as constant as possible, and the preparation method should be standardized, otherwise the clotting time will be prolonged or shortened, or the normal value will be irregular. Conditional laboratories can use buffered anticoagulants, which are more suitable for analysis of specimens after cryopreservation. The function of the buffer is to maintain a constant pH value of plasma and prevent the inactivation of volatile factors.
1ã??Anticoagulation mechanism
Citrate is mainly sodium citrate. The principle of anticoagulation is to combine with Ca2+ in the blood to form a chelate, so that Ca2+ loses coagulation function. Calcium is an essential substance in the coagulation process and can promote the formation of thromboplastin (coagulation factor III), thrombin and fibrin. And activate the release response of platelets. Citrate ions in citrate and calcium ions in the blood form a soluble complex calcium citrate that is difficult to dissociate. This complex is easily soluble in water but not easily dissociated, reducing calcium ions in the blood and clotting. The process is inhibited, thereby preventing blood clotting.
2ã??Clinical application
Sodium citrate and blood are used at a ratio of 1:9.
Most coagulation tests can be used for anticoagulation with sodium citrate, which helps stabilize factor V and factor VIII, and has little effect on average platelet volume and other coagulation factors. It can be used for platelet function analysis.
Sodium citrate is less cytotoxic, and it is also one of the components of blood maintenance liquid in blood transfusion.
3ã??Notes
6mg of sodium citrate can be used to anticoagulate 1ml of blood, which is strong alkaline; also because of its weak anticoagulant effect and strong alkaline, it is not suitable for blood tests and biochemical tests. Use 5 to 7% sodium citrate solution for acute blood pressure experiments.
Desheng is a veteran blood testing reagent company with 15 years of R&D and production experience, and has in-depth research on blood collection tube additives.
Food Chemical And Additives Sodium Citrate
Specification: Characters White Crystals Identification Passes test Clarity and color of the solution Clear and colorless Acidity or Alkalinity Passes test Tartrate Passes test Chlorides 50 ppm Sulphates 150 ppm Oxalates 100 ppm pH-Value in 5% solution 7.5-9.0 Heavy metal(as Pb) 5 ppm Arsenic(as As) 1 ppm Lead 1 ppm Mercury 1 ppm Readily carbonise substances Not deeper than standard Pyrogens Passes test Loss on drying 11.0-13.0 % Purity 99.0-101.0 %
Product Name: Sodium Citrate "Type: Food Additives Origin: China CAS No.: 6132-04-3 AUCO No.: 106 Packing: 25kg bag" Items Standard Characters White Crystals Powder Identification Passes test Clarity and Color of Solution Clear and colourless Acidity or Alkalinity Passes test Tartrate Passes test Chlorides 50 ppm Sulphates 150 ppm Oxalates 100 ppm PH-Value in 5% solution 7.5-9.0 Heavy Metal (as Pb) 5 ppm Arsenic (as As) 1 ppm Lead 1 ppm Mercury 1 ppm Readily Carbonisable Substances Not deeper than standard Pyrogens Passes test Loss on drying 11.0%-13.0% Purity 99.0%-101.0% Particle Size 30-100mesh Packing 25kgs net paper bag, 400bags/10mts. Storage Store in cool, dry place in well-closed containers.
Sodium Citrate Type: Food Additives Origin: China CAS No.: 6132-04-3 AUCO No.: 106 Packing: 25kg bag
Item Quality Standards Characters White or almost white, crystalline powder or granular Identification Pass test Appearance of solution Pass test Assay 99.0%~100.5% Water 11.0%~13.0% Readily carbonisable substances Pass test Acidity or alkalinity Pass test PH (5%w/v) 7.5~9.0 Sulfate â?¤150 mg/kg Oxalate â?¤100 mg/kg Chloride â?¤50 mg/kg Lead â?¤1 mg/kg Arsenic â?¤1 mg/kg Mercury â?¤1 mg/kg Heavy metal (as Pb) â?¤10 mg/kg Tartrate Pass test Pyrogen Pass test Bacteria Endotoxins Pass test
Sodium Citrate, E331, CAS no.68-04-2, the sodium salt of Citric Acid, also called trisodium citrate, colorless crystals or white crystalline powder soluble in water. Sodium Citrate used as a food additive, usually for flavor or as a preservative. Along with other salts of citric acid, such as Magnesium Citrate, Calcium Citrate and Potassium Citrate. As an experienced Sodium Citrate manufacturer and supplier, we has been supplying and exporting Sodium Citrate for almost 10 years, please be assured to buy from us. Any inquiries about price and the market trend please feel free to contact us, we will reply you within 1 working day. Sodium Citrate Specification ITEM STANDARD CHARACTERISTIC WHITE CRYSTAL POWDER IDENTIFICATION PASS TEST APPEARANCE OF SOLUTION PASS TEST ALKALINITY PASS TEST LOSS ON DRYING 11.00-13.00% HEAVY METALS NOT MORE THAN 5PPM OXALATES NOT MORE THAN 100PPM CHLORIDES NOT MORE THAN 50PPM SULPHATES NOT MORE THAN 150PPM PH VALUE (5% AQUEOUS SOLUTION) 7.5-9.0 PURITY 99.00-100.50% READILY CARBONISABLE SUBSTANCES PASS TEST PYROGENS PASS TEST ARSENIC NOT MORE THAN 1PPM LEAD NOT MORE THAN 1PPM MERCURY NOT MORE THAN 1PPM
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Sodium Citrate Dihydrate also known as Tri-sodium Citrate is the most broadly used emulsifying salt in sliced processed cheese products. It is commonly used as a buffering agent in combination with citric acid to provide precise pH control required in many food and beverage applications. In meat products it is used as a anticoagulant of fresh livestock blood and as a curing accelerator. It is used in blood samples as an anticoagulant and in photography. Sodium Citrate Dihydrate (Tri-Sodium Citrate) USP/ FCC/ NSF WC Code: 19-014-01 Sales Specification Appearance: White Crystalline Powder Assay: 99.0% to 100.5% Solubility: Free soluble in water, very soluble in boiling water, insoluble in alcohol Identification (A & B): As per USP Alkalinity: As per USP Water: 10.0% to 13.0% w/w Tartrate: As per USP Heavy Metals: NMT 10 PPM Packing 50 LB bag 48 bags per pallet
[Product Name] Sodium Citrate [Package Specification] 500g/bottle [Product Performance] White crystal powder, easy to absorb moisture. [Application] It can be used as flavor agent and stabilizer in food and beverage industry, as anticoagulant, expectorant and diuretic in pharmaceutical industry; In detergent industry, it can replace sodium tripolyphosphate as the additive of non-toxic detergent. It is an excellent chelating/complexing agent in chemistry and has been used in many industrial applications of sodium citrate. It is also used in brewing, injection, photographic drugs electroplating,etc. [Special storage conditions and methods] sealed and moisture-proof. [validity] 3 years (subject to the production date). Desheng is an old brand blood test reagent company with 14 years of R&D and production experience. It has a deep research on blood collection additives. If you need any business friends of irumino, you can contact 15071057533 (wechat with the same number) directly. We are looking forward to your call! Desheng is an established blood test reagent company with 14 years of R&D and production experience. It has a lot of research on blood collection additives. Enterprises or individuals in need of sodium citrate can
