SV40 NLS Simian virus 40 nuclear localization signal
3xNLS 3 tandem simian virus 40 nuclear localization signal
c-MYC NLS Nuclear localization signal of human c-MYC gene
MITO Mitochondrial targeting sequence from human cytochrome c oxidase subunit VIII gene
Ig_Sig Murine Ig kappa chain leader sequence
Chemical modification is the key to improving pairing affinity, metabolic stability, and cellular uptake of RNA and absolutely essential in the discovery and development of highly active RNA therapeutic candidates. Therefore, many of the chemical modifications have been developed to introducing into RNA oligo to improve their thermal stability, serum stability, cellular activity, or pharmacokinetic properties. For instance, the replacement of phosphodiester with phosphorothioate (PS) linkages will reduce cleavage by nucleases and increase the half-life of oligonucleotides in vivo.
As a leading biotechnology company in the world, Creative Biogene possesses sophisticated equipments, advanced technologies and highly experienced staff which are available to provide you with a series of high-quality adjuvants products for your vaccine development, such as Freund's adjuvant, bacteria-derived adjuvants, toll-like receptor agonists and CpG ODNs. Creative Biogene's goal is to provide you with the most affordable and high-quality adjuvants products to ensure your satisfaction in a timely and professional manner.
