Nobiletin is a citrus flavonoids isolated from citrus peels, similar to tangeretin structure. It has the typical flavonoid structure and contains 6 methoxyl groups. It is an o-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.Pure nobiletin has the appearance of colorless needles and has a bitter taste.
Most studied properties of nobiletin are its anti-inflammatory and anti-cancer activities. Nobiletin also helps to lower cholesterol levels and some studies indicate that it may improve impaired memory loss and treat acne.
Nobiletin acts directly as an antioxidant but also interferes with biological inflammatory processes. It inhibits the expression of genes involved in inflammation by blocking the binding of nf-kappab with dna. One study showed that nobiletin reduced airway inflammation of asthmatic rats. Treatment of skin cells with nobiletin also reduced inflammation caused by ultraviolet-b.Radiation.
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