This ingredient is mainly used for skin care supplement & skin care cosmetics because this is effective in the activity of the natural killer cell, the number of the outstanding pores, the pigmentation small, pigmentation size, brightness, a reddish tinge, water value (moisture), an oil value, etc which we already tested. The original effective is for reinforcement of the intestinal tract immunity. 2nd is for activation of the whole by cell by means of the improvement of bloodstream for circulatory organ and alimentary system. We understand that proteoglycan has a direct effect of the reinforcement of the intestinal tract immune cell, and it has indirect of activation of the whole body cell by means of improvement of the bloodstream. We already tested the activity of NK cell & the effect of the improvement of bloodstream. We also tested to relieve a symptom of the ulcerative colitis by proteoglycan. Furthermore, we understand that this ingredient is effective in anti-tumor because proteoglycan is combined with TLR4 (Toll-like receptor 4) of dendritic cell, and it activates / stimulate NK cell & NKT cell. As everybody has proteoglycan in body, it is very safe ingredient.