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OVCHECK have secured a marker that can diagnose ovarian cancer with an accuracy of 95% or higher (sensitivity of 100% and specificity of 91%), and the project is currently in the clinical validation stage. OVCHECK DEVELOPMENT PROCESS Bertis is currently developing a highly accurate early ovarian cancer diagnosis technology with Seoul National University Hospital Gangnam Center. The tumor markers CA125 and HE4, the conventional biomarker for ovarian cancer testing, have limitations in the early screening of ovarian cancer due to their low sensitivity and specificity. Bertis is developing a technology that enables a more accurate diagnosis of ovarian cancer and is currently in the clinical verification stage by securing markers to diagnose ovarian cancer with more than 95% accuracy (100% sensitivity and 91% specificity).
PANCCHECK is a blood test solution that enables early diagnosis of pancreatic cancer with 94% accuracy is under development. PANCCHECK DEVELOPMENT PROCESS: While effective early diagnostic methods for pancreatic cancer are currently lacking, BERTIS is developing a technology that enables early diagnosis of pancreatic cancer with a small blood sample. Through research, we have identified 10 protein biomarkers as a diagnostic marker panel for pancreatic cancer. Following algorithm development and validation, we have uncovered a combination of markers that demonstrates a high accuracy of 98% and is applicable in clinical settings.
Global proteomics (Cell, Tissue, blood proteome) Label-free analysis based on data-independent acquisition (DIA). Our industry-leading protein analysis of non-depleted plasma can result in 1,300 protein identifications in one-hour per single sample. Our isotope-labeling enables a sample-to-sample comparison analysis in protein quanti�cation. Bertis labeling quantification and advanced fractionation technology enable industry-leading protein quantification analysis in cell or tissue samples. Our phospho/glyco proteomics ensures high-quality post-translational modification (PTM) analysis of proteins, providing an optimized solution for biomarker discovery and mechanism of action analysis. Our bioinformatics analysis provides your research needs from basic analysis of protein composition and quantiy cation to in-depth systems biology analysis. We provide analysis services that meet our customer's needs through continuous communication and interaction.
Companion Diagnostics (CDx) provide a companion diagnostic solution through pathway analysis based on RNA and protein quantification information respective to subtypes from each diseases. For precision medicines developed based on multi-omics analysis, biomarkers can be used to identify target patients in advance. Global pharmaceutical companies are active in the use of companion diagnostics as a key strategic tool in clinical development programs. PASS provides solutions for the entire process from discovery of drug candidates to non-clinical to clinical trials through pan-omics technology. Bertis has array of innovative and reliable technology to increase the safety and efficacy of an investigational drug across the clinical research landscape, including solutions for the discovery of biomarkers for companion diagnostics and the determination of clinical targets through functional analysis.
Protein Characterization (Physicochemical property of proteins) structure analysis using mass spectrometry provides results that meet the requirements of the FDA, the MFDS and other regulatory authorities regarding novel therapies or biosimilars. Based on basic amino acid analysis (full sequencing), we perform post-translational modification (PTM) analysis, which is important for protein potency and stability. In this regard, we can perform test methods based on design of experiment (DOE) statistical methodology and deliver documents to be submitted to regulatory authorities. Protein identification and quantification : Structural analysis of all types of protein therapeutics, including monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), and enzymes - Full Length-Amino acids sequencing Peptide identification of each peak through peptide mapping (MS spectrum confirmation, MS/MS spectral analysis with 100% AA matches) - Improved N- and C-terminal sequencing of proteins Post-translational modification (PTM) : More reliable results based on design of experiment (DOE) statistical methodology to perform the experiments systematically and analyze data efficiently - Disulfide bond analysis ID Total possible lankage analysis - Deamidation identification and quantification - Phosphorylation identification and quantification , phospho-proteomic analysis - Other functional modifications Glycomics : Single protein analysis and research of protein complexes with glycosylation closely related to biological function and toxicity as well as structural stability of proteins - Glycosylation site determination - Glycan profiling - Site-specific glycan identification and quantification - Glycomics research with glycan enrichment
Medical Equipments
"Factview Urine Strip Glucose & Protein 2P" likely refers to a specific product or brand of urine test strip used for the qualitative detection of both glucose and protein in urine samples. These urine test strips are commonly used in healthcare settings for routine urinalysis to screen for various substances, including glucose and protein, which can indicate various health conditions when present in abnormal levels. Here's how they typically work: Sample Collection: A urine sample is collected from the patient. This sample is usually collected in a clean container and may be collected at any time of the day. Dipping the Strip: The urine test strip is dipped into the urine sample for a few seconds, ensuring that all the reagent pads on the strip are fully immersed in the urine. Reaction with Glucose and Protein: If glucose and protein are present in the urine sample, they will react with the respective reagents on the strip. This reaction typically produces color changes on the reagent pads corresponding to the concentrations of glucose and protein in the urine. Interpretation of Results: After a specified reaction time (usually a few minutes), the color changes on the reagent pads are compared to a color chart provided by the manufacturer. This chart helps determine the approximate concentrations of glucose and protein in the urine sample. A "Glucose & Protein 2P" urine strip indicates that it is specifically designed to detect both glucose and protein in urine and may have two separate pads (2P) for detecting each substance. These strips are useful for screening for conditions such as diabetes mellitus (glucose) and kidney disease or urinary tract infections (protein), where abnormal levels of these substances may be present in the urine. It's important to note that urine testing using test strips provides qualitative results and may not be as accurate as laboratory-based quantitative measurements of glucose and protein levels in urine. Therefore, any abnormal results obtained using urine test strips should be confirmed with further diagnostic tests for accurate diagnosis and management.
These urine test strips are commonly used in healthcare settings, including clinics, hospitals, and laboratories, as well as for at-home testing purposes. They are designed to provide a quick and convenient method for screening for various substances, including glucose, in urine. Here's how they typically work: Sample Collection: A urine sample is collected from the patient. This sample is usually collected in a clean container and may be collected at any time of the day. Dipping the Strip: The urine test strip is dipped into the urine sample for a few seconds, ensuring that all the reagent pads on the strip are fully immersed in the urine. Reaction with Glucose: If glucose is present in the urine sample, it will react with the reagent on the strip. This reaction typically produces a color change on the reagent pad corresponding to the concentration of glucose in the urine. Interpretation of Results: After a specified reaction time (usually a few minutes), the color changes on the reagent pads are compared to a color chart provided by the manufacturer. This chart helps determine the approximate concentration of glucose in the urine sample. A "Glucose 1P" urine strip may indicate that it is specifically designed to detect glucose in urine and may have a single pad (1P) for detecting glucose. These strips are useful for screening for conditions such as diabetes mellitus, where elevated levels of glucose may be present in the urine. It's important to note that urine glucose testing using test strips provides qualitative results and may not be as accurate as laboratory-based quantitative measurements of glucose levels in blood. Therefore, any abnormal results obtained using urine test strips should be confirmed with further diagnostic tests, such as blood glucose measurement, for accurate diagnosis and management.
The HCV (Hepatitis C virus) device is a medical tool used to detect the presence of the hepatitis C virus in blood samples. Hepatitis C is a viral infection that primarily affects the liver and can lead to both acute and chronic forms of hepatitis. Similar to the HbsAg device, the HCV device typically employs immunoassay techniques to detect the presence of antibodies or antigens associated with the hepatitis C virus in the blood sample. These techniques may include enzyme-linked immunosorbent assay (ELISA), chemiluminescent immunoassay (CLIA), or rapid diagnostic tests (RDTs). The device provides qualitative or quantitative results, indicating whether the virus or its components are present in the sample and sometimes providing information about the viral load, which can help in monitoring the progression of the infection and the effectiveness of treatment. Effective diagnosis of hepatitis C using such devices is crucial for timely treatment initiation, preventing disease progression, and reducing the risk of transmission to others. Early detection can significantly improve patient outcomes and reduce the burden of hepatitis C-related liver disease.
The HbsAg (Hepatitis B surface antigen) device is a medical tool designed to detect the presence of the hepatitis B virus surface antigen in blood samples. Hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic disease. The device typically works by utilizing immunoassay techniques, where antibodies specific to the HbsAg antigen are used to capture and detect the antigen in the blood sample. This detection can be qualitative, indicating whether the antigen is present or not, or quantitative, providing information on the concentration of the antigen in the sample. These devices play a crucial role in diagnosing hepatitis B infection, screening individuals for the virus, and monitoring patients' response to treatment. Rapid and accurate detection of HbsAg is essential for timely intervention and management of hepatitis B infection to prevent complications and transmission of the virus.
Disposable adhesive cardiac electrode pads are medical devices used in electrocardiography (ECG) procedures to detect and record the electrical activity of the heart. Here's more information about these pads: Purpose: The primary purpose of disposable adhesive cardiac electrode pads is to securely attach ECG electrodes to the patient's skin, allowing for the acquisition of clear and accurate ECG signals. These pads serve as the interface between the patient's body and the ECG monitoring equipment. Design: Disposable adhesive cardiac electrode pads are typically made of soft, flexible material, such as foam or fabric, with an adhesive backing that adheres to the patient's skin. They are designed to be comfortable for the patient while ensuring reliable electrode contact and signal transmission. Electrode Placement: Disposable electrode pads are pre-gelled with conductive gel to ensure good electrical conductivity between the skin and the electrodes. They are usually pre-positioned on a backing material or individually packaged for easy application to specific locations on the patient's body, such as the chest, limbs, or torso. Adhesive Properties: The adhesive backing of the electrode pads is formulated to adhere securely to the skin without causing discomfort or irritation. It should provide strong adhesion throughout the duration of the ECG procedure, even during patient movement or perspiration. Compatibility: Disposable adhesive cardiac electrode pads are compatible with various types of ECG machines and monitoring equipment, including 3-lead, 5-lead, and 12-lead ECG systems. They are suitable for use in hospitals, clinics, ambulances, and other healthcare settings. Disposable: As indicated by their name, disposable adhesive cardiac electrode pads are intended for single-use only. After the ECG procedure is complete, the pads are removed from the patient's skin and discarded according to medical waste disposal protocols. Hygiene: Disposable electrode pads help maintain hygiene and reduce the risk of cross-contamination between patients. They should be stored in a clean and dry environment before use, and proper hand hygiene practices should be observed when applying and removing the pads.
Aqua gel, also known as ultrasound gel or coupling gel, is a specialized gel used as a medium to transmit ultrasound waves between the transducer probe and the patient's skin during various medical imaging procedures such as ultrasound imaging (USG), cardiotocography (CTG), and fetal Doppler monitoring. Here's more information about aqua gel for USG, CTG, and fetal Doppler: Purpose: The primary purpose of aqua gel is to serve as a conductive medium that facilitates the transmission of ultrasound waves between the ultrasound probe and the patient's skin. This allows for the production of high-quality ultrasound images and accurate Doppler signals during imaging and monitoring procedures. Composition: Aqua gel is typically water-based and contains ingredients that provide viscosity, lubrication, and acoustic coupling properties. Common ingredients may include water, glycerin, propylene glycol, cellulose derivatives, preservatives, and sometimes colorants or fragrances. Conductivity: Aqua gel is formulated to have optimal acoustic properties, ensuring efficient transmission of ultrasound waves while minimizing air pockets or impedance that could degrade image quality or Doppler signals. High-quality aqua gel ensures clear visualization of anatomical structures and accurate assessment of blood flow. Viscosity: The gel's viscosity is designed to be suitable for easy application and spreadability on the skin without dripping or running. It should provide sufficient contact between the ultrasound probe and the skin surface while allowing for smooth movement during scanning. Non-Irritating: Aqua gel is typically formulated to be hypoallergenic, non-greasy, and non-irritating to the skin. It should be gentle and comfortable for patients, even those with sensitive skin, to ensure a positive imaging or monitoring experience. Compatibility: Aqua gel is compatible with a wide range of ultrasound transducers and probes used in various medical imaging applications, including abdominal, obstetric, vascular, cardiac, and musculoskeletal ultrasound examinations. It is suitable for use with both standard and specialized ultrasound equipment. Application: Before applying aqua gel, the skin should be cleaned to remove any oils, lotions, or dirt that may interfere with ultrasound transmission. A generous amount of gel is then applied to the skin at the imaging or monitoring site before placing the ultrasound probe or Doppler transducer. Hygiene: Aqua gel should be stored in a clean and dry environment to prevent contamination. Single-use disposable packets or bottles with dispensing caps are commonly used to maintain hygiene and prevent cross-contamination between patients.
Tear Test Strips, specifically those of the Schirmer type, are diagnostic tools commonly used in ophthalmology to measure tear production. Here's more information about Tear Test Strips of the Schirmer type: Purpose: Tear Test Strips (Schirmer) are primarily used to assess the quantity of tears produced by the lacrimal glands. This test helps diagnose conditions such as dry eye syndrome, also known as keratoconjunctivitis sicca, by evaluating tear production levels. Design: Schirmer Tear Test Strips are thin, paper-like strips that are usually marked with millimeter (mm) gradations. The strips are typically designed to be inserted into the lower eyelid's conjunctival sac, where they absorb tears over a specified period. Packaging: Tear Test Strips (Schirmer) are commonly packaged in individual packets or vials to maintain sterility and prevent contamination. A pack of 100 Tear Test Strips would contain 100 individual strips, each sealed in its own packet. Usage: To perform the Schirmer Tear Test, a single strip is inserted into the lower eyelid's conjunctival sac, usually at the outer corner of the eye. The patient is instructed to keep their eyes closed during the test, which typically lasts for a few minutes. After the specified time, the strips are removed and the amount of tear wetting is measured using the mm gradations on the strip. Interpretation: The length of tear wetting on the Tear Test Strip (Schirmer) provides an indication of the quantity of tears produced by the lacrimal glands. Reduced tear wetting may indicate decreased tear production, which can be indicative of dry eye syndrome or other ocular surface disorders. Variations: There are variations of the Schirmer Tear Test, including the Schirmer I test (without anesthesia) and the Schirmer II test (with anesthesia). The Schirmer I test measures basal tear secretion, while the Schirmer II test evaluates reflex tear secretion after instillation of anesthetic eye drops. Safety and Precautions: Tear Test Strips (Schirmer) should be handled and disposed of according to standard precautions for ocular diagnostic procedures. Care should be taken to avoid contamination and ensure accurate test results.
