Hydroxychloroquine sulfate was synthesized from surrey and hammer in 1946. Hydroxychloroquine sulfate has antipyretic, arthritis and eliminate rash inhibition, its anti-inflammatory and immune suppression and immune regulating mechanism in the complex. In the 1950 s, along with antimalarial drugs in systemic lupus erythematosus (sle) and rheumatoid arthritis (ra) is the application of the treatment, the curative effect of hydroxychloroquine sulfate used in the treatment of the rheumatic diseases for sure. Hydroxychloroquine sulfate used in systemic lupus erythematosus (sle) and rheumatoid arthritis (ra) and so on the treatment of rheumatism, safe, effective and well tolerated. Since the 1990 s, more than 90% of clinical treatment of rheumatism choose hydroxychloroquine sulfate. 10*15*20