Product Name: Propionyl-L-Carnitine Hydrochloride Other Name: Levocarnitine Propionate Hydrochloride Molecular Formula: C10H20ClNO4 Molecular Weight: 253.72 Appearance: white or almost crystalline powder Purity: 99.3% CAS Number: 119793-66-7 EINECS number: 922-939-3 Supplier: ZHENYIBIO Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during �²-oxidation of uneven chain fatty acids. Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto-prostaglandin F1�± (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells. It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal. Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.
