Baicalin is an active component of Scutellaria Baicalensis Extract. It can cross the blood-brain barrier and distribute in cerebral nuclei. However, its mechanism and the effects on the nuclei where it accumulates remain unclear. We used an HPLC-electrochemical detection method to determine the dopamine in cerebral nuclei after intravenous administration of flavonoids from Scutellaria Baicalensis and analyzed the relativity between baicalin and DA in cerebral nuclei. We found that the dopamine system is another target system of brain function which baicalin acts on.
CAS NO: 21967-41-9
Product Name: Scutellaria Baicalensis Extract
Latin Nameï¼? Scutellaria Baicalensis Georgi
Chemical name: β -D-Glucopyranosiduronic acid, 5,6-dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl
Part of Plant Used: Root
Active Ingredient: Baicalin 80%~98%
Test Method: HPLC
Appearance: Light-yellow fine powder
Odor: Characteristic
Taste: Characteristic
Partical Size: 80 Mesh
Molecular Formulaï¼? C21H18O11
Molecular Weightï¼? 446.36
Baicalein Attenuates Kidney Injury Induced by MI and Reperfusion on DWN RENAL
Acute kidney injury is a common and severe complication of acute myocardial infarction and cardiac surgery. It results in increased mortality, morbidity, and duration of hospitalization. Baicalin is a component of the root of Scutellaria baicalensis, which has traditionally been used to treat cardiovascular and liver diseases in Asia. In this study, we investigated whether baicalein can attenuate kidney injury induced by myocardial ischemia and reperfusion in rats.
Myocardial ischemia and reperfusion, induced by a 40-minute occlusion and a 3-hour reperfusion of the left anterior descending coronary artery, significantly increased blood urea nitrogen and creatinine levels in addition to causing histological changes in the kidneys. Kidney apoptosis was also significantly increased. Furthermore, myocardial ischemia and reperfusion significantly increased the serum levels of tumor necrosis factor-�±, interleukin-1, and interleukin-6 as well as the tumor necrosis factor-�± levels in the kidneys.
Intravenous pretreatment with baicalein (in doses of 3, 10, or 30â??mg/kg), however, significantly reduced the increasesin the creatinine level, renal histological damage, and apoptosis induced by myocardial ischemia and reperfusion. In addition, the increases in the serum levels of tumor necrosis factor-�±, interleukin-1, and interleukin-6, and of tumor necrosis factor-�± in the kidneys were significantly reduced. Western blot analysis revealed that baicalein significantly increased Bcl-2 andreduced Bax in the kidneys.
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