* Filler is the substances (mainly collagen and hyaruronic acid) injected into skin or subcutaneous fat to correct wrinkles or scars are termed filler. * HyaFilia is injected around skin layer of the wrinkled area of face for the temporal improvement of wrinkle. HyaFilia contains non-animal, stabilized gel-type hyaluronic acid which is colorless and transparent with viscoelasticity * HyaFilia contains stabilized hyalruronic acid derivatives to overcome the short time degradation problem of hyaluronic acid. * Through the in vivo enzyme activity, HyaFilia is degraded and absorbed after the certain time period * HyaFilia is proved its safety and efficacy through the domestic multi-center comparison clinical test, and it obtained the KFDA certification (2013.05) and Europe CE certification (2012.02)