It is helpful in treating rheumatoid arthritis, osteoarthritis, post-herpetic neuralgia, painful diabetic neuropathy and other peripheric sensorial neuropathies. It is also used in treating muscle, joint discomforts, as well as rheumatism, sciatica and lumbago. Capsicum oleoresin is a natural extract obtained from capsicum annuum. Its most important active ingredient is the capcaicin, which gives the pepper its bitterness. Vanilloids are mostly in interaction with receptors located at peripheral nerves. Capsaicin is connected to C-Type vanilloid receptors (VR1) starts calcium flow by causing the cation channels to be opened. Calcium flow is an excitatory response, and it starts the release of neuropeptites (P substance). Neuropeptides are responsible for chemically-born pain, heat regulation and neurogenic inflammation. With the blockage of calcium channel, P substance shall be depleted in sensual fibers With the blockage of calcium channel, P substance depletion occurs in sensual fibers and, as a result, pain loss is achieved. Camphor inhibits a wide range of different receptors. When induced by camphor, desensitization occurs in TRPV1 (transient receptor potential vanilloid subtype 1), and the blockage of TRPA1 (transient receptor potential ankyrin-repeat) receptor takes place. These form the basis for the analgesic effects of camphor. Menthol is one of the main ingredients of the essential oil obtained from mint. It is used for the treatment of inflammation, spasm and pain and applied from inside or outside (superficially). After the topical application, menthol inhibits the calcium ion currents of the nerve membranes by stimulating the "cold" receptors, and creates a feeling of coolness.