Physical and Chemical Properties THF is a colorless transparent liquid and THF density is 089gcm3melting point is 1085boiling point is 66flash point 14 CC refractive index is 1465 20 structure C4H8O THF Acute toxicity LD501650mgkg rat transoral LC5021000ppm Rat inhalation 3h THF is soluble in water ethanol ether acetone benzene etc mainly used as solvent chemical synthesis intermediates analytical reagents Tetrahydrofuran THF Uses Tetrahydrofuran as a fine reaction intermediate can be used as a natural flavor enhancer for tetrahydrothiophene Tetrahydrofuran is used in medicine to produce carbetapentane citrate progesterone rifumycin etc Tetrahydrofuran can be used in chemical production to prepare polytetrahydrofuran tetrahydrothiophene 1 4dichlorobutane 2 3dichlorotetrahydrofuran valerolactone ethanediamine 1 4butanediolgammabutyrolactone and many other chemical products Tetrahydrofuran can also be used as high energy fuel acetylene extraction solvent electroplating coating liquid precision tape cleaning agent leather surface finishing agent light stabilizer of molecular materials etc The most important use of THF tetrahydrofuran is to produce PTMEG According to rough statistics about 80 of THF in the world is used to produce PTMEG and PTMEG is mainly used to produce spandex fiber