Diaminopyrimidine Oxide for hair loss. INCI Name: Diaminopyrimidine Oxide Chemical name: 2,4-Diaminopyrimidine 3-N-Oxide Synonyms: 2,6-Diaminopyrimidine 1-Oxide; Aminexil; CAS No.: 74638-76-9 Chemical Formula: C4H6N4O Molecular Weight: 126.12 Appearance: White to off-white powder Purity: 99.0% Maximum Recommended Addition Dose: 1.5%  Application: hair products Physicochemical Property: white crystalline granular, low water-solubility. a chemical compound used to increase the volume of hair in the growth stage by working on the deep structure of the roots. It rejuvenates the hair roots so that healthy hair growth can persist. The perifollicular fibrosis is a condition in which collagen around the roots becomes rigid, tightens, and pushes the hair out. helps in softening of the collagen. acts as a hair growth stimulant. It strengthens hair root, thickens hair and prevents premature hair loss. is used in serum, spray, oils, lotions, gels, conditioners and shampoos for hair. It is also used in eye liners and mascaras. a substance designed to counteract hair loss. Already in small doses the substance is active to stop the hair loss. , similar to Minoxidil, shows activation of IGF, EGF, and downregulates the production of TGF-beta 2 and IL-1. The advantage over Minoxidil is that the substance actively combats hair loss in very small doses as low as 0.5% and thus shows no systemic side effects such as Minoxidil. Another advantage over Minoxidil is that in small concentrations stimulates hair growth but does not prolong the telogen stage. soften the rigid collagen around hair follicles by inhibiting lysine hydroxylase mRNA expression. preventing perifollicular fibrosis by stimulating collagen formation and inhibiting the premature exhaustion of the hair root. Compared with minoxidil, has no effect on blood pressure and better safety. Hair loss is influenced from all sides, The combination of kopexil and Kopyrrol, a mutual potentiation of the growth effect is triggered on the hair, but without triggering an increased apoptosis of the hair roots. The combination of kopexil and Kopyrrol will result in strong hair growth, significantly stronger than just with kopexil or minoxidil alone.