EUK-134 INCI Name: Ethylbisiminomethylguaiacol Manganese Chloride CAS Number: 81065-76-1 Appearance: Dark brown to reddish powder Solubility: H2O: 2 mg/mL, clear (warmed); Soluble in DMSO storage temp: 20 C ADVANTAGES Both superoxide dismutase (SOD) and catalase (CAT) activities Self-regenerating property Smaller molecular weight High stability RECOMMENDED FOR Skin care (Facial care, Facial cleansing, Body care, Baby care) Sun care (Sun protection, After-sun & Self-tanning) APPLICATIONS Antioxidant UV protection Protect against DNA damage DNA repair Anti-inflammatory Anti-irritation Anti-stress Sunscreen care, supplement the care that general sunscreen ingredients can t take care of EUK-134 is a highly purified molecule and a multi-functional, super antioxidant and powerful free radical scavenger with self-regenerating property. It is a synthetic mimetic of two natural skin enzymes: catalase and superoxide dismutase. It protects against free radicals, DNA damages and reduces erythema and redness. It helps prevent premature aging and scavenges superoxide free radicals, eliminates hydrogene peroxide (H2O2) and transforms reactive oxygen species(ROS) into water and oxygen which are beneficial for the skin. It protects skin tissue against toxic compounds, protects skin against UV-induced DNA damage leading to limit premature photo-aging. It inhibits MMP-2, thus preserving a good ECM network. It reduces damages caused by UV and skin free radical activity. It is used in prevention of DNA damage, repair DNA, brighten skin tone, anti-irritant, anti-stress, anti-inflammatory, antioxidant and sun care products. It is complementary to SPF ingredient. EUK-134 has dual antioxidant function i.e. superoxide dismutase and catalase mimetic activities.Its therapeutic use and studies conducted are based on its property to reduce reactive oxygen species (ROS) induced cellular injury in the body. It is a  low-molecular-weight synthetic complex that has better potency, stability, and bioavailability than endogenous antioxidant enzymes. EUK-134 can act as a scavenger for oxidative species such as hydrogen peroxide, peroxynitrite and superoxide. This compound is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity. EUK-134 has the unique and amazing capacity of regenerating itself during its free radical scavenging action. Thereby, EUK-134, represents a complete nature mimetic antioxidant system that can be used as an active cosmetic ingredient to limit premature aging, reduce photo-aging, protect the skin and its DNA from sun damage and decrease redness.