Organic Probio is made from 32-plant fermnted extract with a rigorously tested, single-strain yeast, developed to effectively deliver enzymes and nutrients deep into the digestive tract. The main probiotics called "ITO Probiotic" yeast was identified in 2016 at Ritsumeikan University, where it was shown capable of tolerating acidity in the pH1.5â??2.0 range. Whereas other supplemental nutrients are destroyed by the stomach acids of the upper digestive tract, plant extracts fermented with the ITO ProbioticTM are acid-tolerant, allowing nutrients and enzymes to survive and support the gut's good bacteria. To maximize its acid-tolerant characteristics, Organic Probio's plant extracts are fermented from 24 to 48 months in a controlled environment.