Guggul (Commiphora mukul), a highly valued botanical medicines has been used for centuaries in ayurveda to treat several ailments.Various extracts of this drug produces guggulipid in that guggulsterone is the active constituent responsible for its therapeutic activity. Invivo, invitro and clinical studies have been conducted to evaluate the pharmacological, phytochemical, and morphological profile of the herb. Studies revealed that guggul contain flavonoids, terpenes, phytosterols etc. producing number of biological activities like anti-inflammatory, antiobesity, antineoplastic, antidiabetic etc. This review is mainly to update information regarding its anti-inflammatory activity.