Gypsum is an evaporate mineral most commonly found in layered sedimentary deposits in association with halite, anhydrite, sulfur, calcite, and dolomite. Gypsum (CaSO4.2H2O) is very similar to Anhydrite (CaSO4). The chemical difference is that gypsum contains two waters and anhydrite is without water. Gypsum is the most common sulfate mineral.