Isolated organ baths are essential tools in pharmacology for studying the effects of drugs on isolated organs or tissues. Here's how they are used: Drug Screening and Testing: Isolated organ baths allow pharmacologists to assess the pharmacological activity of drugs on specific organs or tissues in a controlled environment. By exposing the isolated tissue to different concentrations of a drug, researchers can observe and measure its effects on physiological parameters such as contraction, relaxation, or electrical activity. Mechanism of Action Studies: Pharmacologists use isolated organ baths to investigate the underlying mechanisms of drug action. By examining how drugs modulate the contractile or electrical properties of isolated tissues, researchers can elucidate the pharmacodynamic pathways involved and gain insights into the drug's mode of action. Receptor Pharmacology: Isolated organ baths are particularly useful for studying receptor pharmacology. Researchers can assess the interaction between drugs and specific receptors present in the isolated tissue by measuring the dose-response relationship and determining the potency and efficacy of various pharmacological agents. Toxicity Testing: Isolated organ baths can also be used to evaluate the toxic effects of drugs on specific organs or tissues. By exposing the isolated tissue to increasing concentrations of a drug, researchers can assess its potential to induce adverse reactions such as tissue damage, impaired function, or cytotoxicity. Drug Development: Isolated organ baths play a crucial role in the early stages of drug development by providing valuable data on the pharmacological properties and safety profile of new drug candidates. Pharmacologists use this information to prioritize lead compounds for further preclinical and clinical evaluation. Teaching and Research: Isolated organ baths are widely used in academic settings for teaching pharmacology principles and conducting research experiments. They provide students and researchers with hands-on experience in experimental pharmacology techniques, allowing them to explore the effects of drugs on biological systems in a laboratory setting. Overall, isolated organ baths are versatile tools that facilitate the study of drug effects on isolated tissues, providing valuable insights into pharmacological mechanisms, drug-receptor interactions, and potential therapeutic applications. They are indispensable instruments in pharmacological research and drug discovery efforts.
The Franz diffusion cell apparatus is a laboratory instrument used in pharmaceutical research to study the release of drugs or active ingredients from topical formulations, such as creams, gels, ointments, or transdermal patches, across biological membranes. Here's how it's used: In Vitro Drug Release Studies: The Franz diffusion cell apparatus is primarily employed for conducting in vitro drug release studies. It consists of two compartments separated by a biological membrane (usually animal or human skin), with the test formulation applied to one side (donor compartment) and a suitable receptor medium (often a buffer solution) in the other side (receptor compartment). Membrane Permeation Studies: The apparatus allows researchers to investigate the permeation of drugs or active ingredients through biological membranes, mimicking the conditions encountered in vivo. By monitoring the concentration of the drug in the receptor medium over time, researchers can quantify the rate and extent of drug permeation across the membrane. Formulation Optimization: Pharmaceutical scientists use the Franz diffusion cell apparatus to evaluate the performance of different topical formulations and optimize their composition for enhanced drug delivery. Factors such as the type of excipients, formulation viscosity, drug concentration, and pH can be varied to assess their impact on drug permeation and skin penetration. Transdermal Patch Evaluation: For transdermal drug delivery systems, such as patches, the Franz diffusion cell apparatus is instrumental in assessing the release kinetics and permeation characteristics of drugs through the skin. This information is crucial for designing patches with optimal drug delivery profiles and ensuring therapeutic efficacy. Skin Penetration Studies: In addition to drug release, the Franz diffusion cell apparatus can be used to investigate the penetration of drugs or active ingredients into different layers of the skin. By analyzing samples collected from various depths within the skin, researchers can assess the distribution and localization of the drug following topical application. Bioequivalence Studies: The Franz diffusion cell apparatus is also utilized in bioequivalence studies to compare the performance of generic and reference topical formulations. By measuring the rate and extent of drug release and permeation, researchers can determine whether the generic formulation is therapeutically equivalent to the reference product.
In pyrogen testing on rabbits, a telethermometer plays a crucial role in monitoring body temperature changes. Here's how it's used: Temperature Measurement: Pyrogen testing involves the administration of a test substance (e.g., potential pharmaceutical products or medical devices) to the rabbit, followed by monitoring for signs of fever (pyrexia). A telethermometer is used to continuously measure the rabbit's body temperature before and after the administration of the test substance. Baseline Measurement: Before conducting the test, baseline body temperature readings are taken to establish a reference point. This helps in identifying any deviations from the normal temperature range during the test period. Detection of Pyrogenic Response: Following the administration of the test substance, the rabbit's body temperature is monitored closely using the telethermometer. An increase in body temperature above a predefined threshold indicates a pyrogenic response, suggesting the presence of fever-inducing substances (pyrogens) in the test substance. Real-time Monitoring: A telethermometer allows for real-time monitoring of body temperature changes, providing researchers with immediate feedback on the rabbit's physiological response to the test substance. This enables prompt decision-making regarding the continuation or termination of the test based on the observed pyrogenic response. Data Recording and Analysis: Telethermometers often come with data recording capabilities, allowing researchers to log temperature measurements at regular intervals throughout the testing period. This data can be analyzed to assess the onset, duration, and magnitude of the pyrogenic response, aiding in the interpretation of test results. Animal Welfare: Continuous temperature monitoring with a telethermometer helps ensure the welfare of the test animals by enabling early detection of fever and prompt intervention if necessary. This minimizes potential discomfort or distress experienced by the animals during the testing process. Overall, the use of a telethermometer in pyrogen testing on rabbits enhances the accuracy, reliability, and efficiency of the testing procedure, ultimately contributing to the safety evaluation of pharmaceutical products and medical devices intended for human use.
Grip strength meters are commonly used in research settings to assess the muscular strength of rodents, including rats and mice. Here's how they are utilized: Muscular Function Assessment: Grip strength meters provide a quantitative measure of the muscular strength of rodents by assessing their ability to grasp and hold onto a horizontal bar or grid with their forelimbs. This measurement reflects the overall neuromuscular function and is particularly useful in studies focused on muscle physiology, aging, neuromuscular disorders, and drug efficacy testing. Phenotypic Characterization: Grip strength measurements can be used as part of phenotypic characterization in animal models. Differences in grip strength between groups of rodents, such as strains, genders, ages, or experimental conditions, can provide insights into genetic factors, aging processes, disease progression, or the effects of interventions. Neurological and Neuromuscular Disorders: Grip strength meters are valuable tools for studying neurological and neuromuscular disorders in rodents. Changes in grip strength can indicate motor deficits associated with conditions such as muscular dystrophy, amyotrophic lateral sclerosis (ALS), spinal cord injury, or peripheral neuropathy. Researchers can use grip strength measurements to track disease progression, evaluate therapeutic interventions, or screen potential drug candidates. Pharmacological Studies: Grip strength assessments are often included in pharmacological studies to evaluate the effects of drugs or treatments on muscular function. For example, researchers can investigate the impact of muscle relaxants, analgesics, or muscle-building agents on grip strength in rodent models. These studies help assess the safety and efficacy of therapeutic interventions targeting muscular function. Aging Research: Grip strength measurements are commonly used in aging research to assess age-related changes in muscular function and frailty in rodents. By longitudinally monitoring grip strength in aging animals, researchers can evaluate the progression of age-related decline in muscular strength and explore interventions to mitigate age-associated deficits. Overall, grip strength meters serve as valuable tools for assessing muscular function and studying a wide range of physiological and pathological conditions in rodent models, contributing to our understanding of neuromuscular biology and the development of therapeutic strategies.
Digital plethysmometers can indeed be used to measure edema in rodent models. Here's how they can be applied for this purpose: Paw Volume Measurement: One common method involves measuring changes in paw volume as an indicator of edema formation. The rodent's paw is placed in a chamber connected to the digital plethysmometer. By measuring the displacement of water or air caused by the paw, the instrument can accurately quantify changes in paw volume over time. Inflammatory Models: In research settings, edema is often induced by inflammatory stimuli such as carrageenan injection or trauma. Digital plethysmometers allow researchers to monitor the progression of edema by measuring changes in paw volume at various time points post-induction. Drug Screening: Researchers can use digital plethysmometers to evaluate the efficacy of anti-inflammatory drugs or compounds in reducing edema formation. By comparing paw volume measurements between treated and untreated groups, the effectiveness of potential therapeutics can be assessed. Genetic Studies: Digital plethysmometers are also useful in studying the genetic basis of edema formation. By comparing edema responses between different strains of rodents or genetically modified models, researchers can identify genes or pathways involved in regulating inflammation and fluid accumulation. Longitudinal Monitoring: Digital plethysmometers enable longitudinal monitoring of edema progression and resolution over time. This longitudinal approach provides valuable insights into the dynamics of edema formation and the temporal effects of interventions.
SUMBEXAUTO LED grill mount strobe lighthead is highly popular, which are used for grille lights, deck lights, on side-view mirrors, bumpers, police vehicles and various other applications. Choose from either white and amber or blue and red lights. 19Flash strobe patterns can synchronize function among multiple light heads. The flexible installation of LED grill strobe light provides vehicles with direct light where is needed. Grille strobe lights are in most cases water-proof to prevent short circuits. Emergency grille lights apply durable materials to withstand all harsh conditions. Â It is an ideal public safety light solution.
Forged Jointless Rings Our company is an eminent company, We are engaged in manufacturing, supplying wide assortment of Forged Jointless Rings for all type of Flange's, Bearing's, Gears, Gaskets manufacturers. These Forged Jointless Rings upto 1.2 meters are offered by us at industrial leading prices. Capacity : Min ID 200 - Upto OD 1200, Length - 350MM (Weight - 1.2 Tons) Services : Forging, Heat Treatment, Proof Machining, Destructive & Non-Destructive testing Material Grades: Mild Steel, Carbon Steel, Alloy Steel, & Stainless Steel
The image PROGRAF iPF6400S printer was designed for professionals in the commercial photography, signage display, reprographic and proofing markets that seek the highest possible standards for quality-control and image reproduction, while maximizing productivity. As an optional add-on to the iPF6400S printer, the SU-21 Spectrophotometer features a scan speed of up to 10 inches per second and can accommodate media of different thicknesses (Canon or non-Canon branded) thanks to the deviceâ??s mobile carriage which opens and closes automatically. The device attaches directly onto the front of the iPF6400S printer and includes a user-switchable UV blocking filter that can be switched on and off according to paper type, eliminating the need to purchase individual sensors.
Bread Improvers are used to improve the quality and palatability of bread made using shorter processes. Benefits of using an improver is that the dough maintains its tolerance and stability during the entire process from mixing, shaping, proofing and baking. This improved tolerance results in greater volume, better crumb texture and superior crust characteristics.The improver can enhance the bread gluten, making the expansion better. It can also make the surface crispy under the condition of high temperature and short time baking. Amylase in improver can produce reducing sugar, making the bread color better.
*Silicon seal,latch *Removable handles *Stainess steel hings *Corner SS#304 bottle openers *With Leak-Proof Drain Plug. External dimension:63.5 37.5 38.5CM (25*14.76*15.16") Internal dimension (cm):51.5 27 28CM (20.27*10.63*11. 02") Carton size (cm):65.5 40.5 42CM (0.11CBM/CTN ) Gross/Net Weight:9.5/8.5KGS (20.94/18.74 LBS) Cold retention: 5days at 77 (25 C) with ice fully filled Container Load Quantity:270PCS/20GP; 550PCS/40GP; 650PCS/40'HQ;
Silicone soft touch smooth feeling oil is also called silicone matting oil, silicone matte oil, etc. It is mainly used for coating silicone-based products. Because of silicone products molded out of the surface are rugged and wrinkled, feeling bad while touch it, generally by spraying soft touch smooth feeling oil to improve the silicone surface effect, make it have have a delicate and smooth feelings, and increase products additional value and selling point. Features: Soft touch smooth feeling, anti-sticking, Reduced friction,dust proof functions.
Type:Stainless Steel Sheets Standard:ASTM, AISI, GB, JIS, DIN, EN Grade:200/300/400/Duplex Series Certification: ISO, AISI, ASTM, DIN, JIS Shape:Flat Technique: Hot Rolled Normal Size:1000*2000mm, 1220*2440mm (4X8), 1500*6000mm Thickness:0.3mm-100mm Width:1000mm-2200mm or as Required Length:2000mm-6000mm or as Required Brand:Tisco, Lisco, Jisco, Zpss, Bao Steel Surface:2b, No.1, Ba, Hl, No.8 Sample:Available Transport Package:Water Proofed Packing, Standard Export Package Specification:304 / 316 stainless steel plate Trademark:TISCO, JISCO, ZPSS, BAO STEEL, LISCO Origin:China
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The DN80 flange is a type of pipe flange commonly used in industrial applications. It has a nominal diameter of 80 millimeters, making it suitable for connecting pipes with a similar diameter. Flanges play a crucial role in joining pipes or connecting them to various equipment, ensuring a secure and leak-proof connection. The DN80 flange is typically made of durable materials such as carbon steel, stainless steel, or alloy steel, which offer high strength and resistance to corrosion. Its standardized design allows for easy installation and maintenance, making it a preferred choice in many industries for ensuring the efficient and safe transfer of fluids.
Main Specifications Operating Temperature Range: -20 to +70 Rated Current and Voltage: 50mA. / 12V DC Insulation Resistance: 100M Dielectric Strength: 250V AC (50Hz or 60Hz) for 60 seconds Contact Resistance: 50m Full Travel: 0.25±0.1mm Operating Force: 1.6±0.5N Strong Features Type: SMD surface-mounted tact switch Operating Life cycles: 50000 Flux proof, Reflow solderable. Sharp click feel with a positive tactile feedback Highly reliable contacts sealed structure. Larger top surface of the stem improve mounting speed.
YSJP-02A Turn left & right stainless steel durable hospital cadaver table Material: High quality 304 stainless steel Dimension: L*W*H (2400mm*780mm*870mm) Electric hydraulic lift, flexible and stable Table top can turn 45�°left & right With two-way auto spaying and adjustable handheld mobile spayer With stainless ruler on table top for measuring length Large-diameter drainage hole and strong exhaust fan Infrared sensor faucet with cold and hot water Y-shaped water filter, water-proof power plug and short-circuit protection system
ZP420 series rotary tablet press is a new type of tablet press machine recently developed by our company. It has novel appearance, reasonable structure, convenient operation, stable running, safe & reliable electrical protection functions, and it meets the latest GMP requirement. It is an ideal model choice for upgrading instead of old ones. Product INTRODUCTION Application This machine is a double-press type continuous automatic tablet press machine for pressing granular raw materials into tablets. It is mainly used in pharmaceutical, chemistry, foodstuff, electronic industries and suitable for pressing a variety of tablets, such as: medicine tablets, candy tablets, calcium tablets, camphor pills, slat tablets and powder metallurgy products.. Features 1.Double press type with high productivity, suitable for mass production of tablets. 2.HMI operation interface is rich and friendly which can display real-time working pressure, rotating speed, output counter, real-time position of main pressure wheel & filling track, etc. 3.Made of stainless steel, the housing is fully closed. The surface of the rotary turret is covered with a hardened layer so that the turret surface is wear resistant. 4.Adopt transparent windows, tableting state can be observed clearly. The windows can be opened, cleaning and maintenance is easy. 5.The machine is equipped with pressure sensor, which can display the working pressure in real time and the machine can stop automatically in case of overpressure. 6.Speed adjustable, operation simple and running reliable. 7.Adopt automatic lubrication system which can fully lubricate the pressure wheels, tracks and punches, so as to extend the machine service life. 8.Adopt powerful motor and high-precision reducer, achieve high torque stable & strong power output. 9.Various safety protection functions (emergency stop, over-pressure stop, door and window lock-protection) 10.Adopt oil-proof, dust-proof and noise proof design.
Horizon Offshore Services is an alliance VA Group of companies (HOSVAG) that provides comprehensive Shipbroking services to its global clients base focused on the offshore oil & gas upstream/ midstream markets. Whilst it is thoroughly integrated Offshore Project Management company offering the full range of services including Sale & Purchase, Chartering, Valuations, Consultancy, Project/ Vessel Financing, Supply & Trading of Energy Commodities, Technical Ship Management, Maintenance and Repairs for all sophisticated offshore production/ drilling & renewable assets. From world known reputable Refinery/ Exporter that is obliged with Full Legal Responsibility, HOSVA Group hereby confirms our Capability and Readiness to enter into a contract for the supply of Petroleum Commodities with Kazakhstan Origin to End Buyers and their official creditworthiness Re-Seller Representatives under the Conditions/ Terms of Kazakhstan Ministry of Energy Export Control Rules and ICC Regulations set forth. We look forward to supply your esteemed Organization with JA1, JP54, EN590, Diesel-Gas D2/ D6 Virgin, LPG/ LNG, UREA N46 petroleum products including unlimited quantities of bonny light crude oil (BLCO) which is sweet light crude oil rated API 32.9 from an officially appointed London based Allocation Holder/ Title Holder, received directly from NNPC Ltd and welcome all diligent GBL-Connect purchase enquiries in due course. We are committed to working with Direct Buyers or Re-Sellers who possess Proof of Funds (BCL) as a demonstration of their financial credibility. These parties are directed to our Flow Chart, which provides a clear understanding of our meticulous transaction processes. If a Re-Seller cannot present Proof of Funds (BCL), we suggest an alternative approach. They may propose a Joint Venture Agreement (JVA) on their end, in coordination with Direct Buyers. This arrangement will also include proof of a Tank Storage Agreement (TSA) as part of the transaction process. Should you have an interest in S&P of fuel products, we are pleased to hear from you. Best Regards, Horizon Offshore Services
Top Five High-performance Electronic Speed Controllers (ESC) for RC Hobby It's a tedious task to select excellent electronic speed controllers. You will see that all the products are marked best when you search them on google. As a motor control expert, Xiongcai has evaluated some top brands of RC hobby BLDC electronic speed controller (ESC) over performance and listed top five of them for you to refer. 1. Castle Creation MAMBA XLX2 Castle is one of the most famous suppliers in RC hobby field, so is the ESC. The MAMBA XLX2 electronic speed controller (ESC) can handle power system of 3-6S Li-Po, 33.6v max, 150A continuous current, BEC 5v -8v, 20A peak, providing outstanding experience. With waterproof design, you can drive it in all weather conditions. 2. HIPRacing FLUX ELH-6S HPIRacingâ??s electronic speed controller (ESC) is engineered for RC cars and trucks racing. A powerful brushless ESC FLUX ELH-6S, with up to 150A continuous current, you can enjoy your skill and all kinds of stunts you can dream of. This product is designed for RC racing, the roaring clamor will get you excited. 3. Spektrum Firma 160A This electronic speed controller (ESC) is released by Horizon Hobby, it has been widely used in its sub-brands like Losi, ARRMA, AXIAL, etc. the most famous collocation must be Losi Baja Rey Desert Truck. With continuous current 160A, this ESC provides a smooth operation and neutral demonstration. Its explosive force is not as strong as HPIRacing Flux ELH-6Sâ??s, but operation is relevantly stable. 4. Traxxas Velineon VXL-6S The advantage of Traxxas RC Cars and Trucks is stability management. The Velineon VXL is not as explosive as HPI Flux ELH-6S is, but it excels in vehicle stability and handling. BEC output 6V, 10A provides excellent loading capacity. The perfect application is its application on Unlimited Desert Racer Truck. 5. Xiongcai E8 (XC E8 ESC) Xiongcai technology is specializing in BLDC electronic speed control (brushless ESC), and is one of the few companies that focuses on BLDC brushless ESC only. The E8 electronic speed controller with system of 3-6S Li-Po, 160A sustainable current, BEC 6A current, 15A peak is must-have for enthusiasts. It is engineered to provide ultimate handling experience. 12 levels of acceleration allow you experience the quick start-up like super car. The team has designed perfect protective measures to secure your motor and power system. For example, the application of active free-wheeling identification technology provides microsecond track and response, reducing MOS generating heat and avoiding excessive current pulse. Wave-by-wave current limiting will control the peak of each wave of current to avoid damaging motor and drivetrain, prolonging service life of power system. Maybe the evaluation is not comprehensive due to driving condition, but you can get general expression on performance of above five electronic speed controllers for selecting a proper one.
Product Introduction The 55-inch 0.88mm LCD Video Wall showcases an ultra-narrow bezel design, ensuring a seamless viewing experience. It supports wide viewing angles, precise color adjustments, and is IP5x certified for dust protection, making it durable for diverse environmental conditions. Features Seamless Large Screens with Extreme-Narrow Bezel The ultra-slim bezel, with its 1.74mm BtoB (Panel Bezel to Panel Bezel), drastically reduces bezel interference and delivers immersive and seamless content on assembled video wall screens. Image Gap Reduction The VH7J-H includes an image improvement algorithm that can reduce image gaps among tiled displays when playing back videos. Objects located on the bezel boundaries are adjusted for a seamless viewing experience Higher Viewing Angle Large screens are usually positioned higher than human eye level. A wide half-luminance angle (40°) enables effective picture quality for video walls. The viewing angle of the VH7J-H is high enough to display vivid colors throughout the screen without any color distortion.
