Cellulase is produced naturally by different symbiotic fungi, protozoa, and bacteria that have the ability to catalyse cellulolysis (the breakdown of cellulose). In reality there are different types of cellulases whose activity is pH-dependent: some are more active in an alkaline environment while others are more active in an acidic or neutral one.
Papain can be used in skin and burn treatments. It has been used in traditional or alternate medicine for its antiseptic and anti-inflammatory properties in treating bedsores, burns, skin ulcers, and wounds. Papain should not be used on open wounds, but is used on dry and healed wounds to remove dead skin.
